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Breast Discomfort with Menopausal Hormone Therapy

Predictors of breast discomfort among women initiating menopausal hormone therapy.

Strenuous exercise lowered the odds of new-onset breast discomfort by almost 50%.

Menopause 2009.

Hormones and Sexual Desire

Associations Among Physiological and Subjective Sexual Response, Sexual Desire, and Salivary Steroid Hormones in Healthy Premenopausal Women.

Cortisol decreased in association with genital sexual arousal and dating women exhibited higher genital sexual arousal than single or partnered women.

J Sex Med. 2008 Dec 5.

Yoga for Menopause

Yoga for menopausal symptoms: a systematic review.

Seven studies were reviewed.  Benefits were only seen in non-randomized or uncontrolled clinical trials.

The conclusion is “the evidence is insufficient to suggest that yoga is an effective intervention for menopause.”

Menopause. 2009 Jan 22.

Estrogen replacement and migraine

Estrogen replacement and migraine.

Women with migraine with aura requiring estrogen replacement should be given the lowest effective dose necessary to control menopause symptoms, by a non-oral route.

Maturitas. 2009 Apr 15.

Cochrane review on exercise for menopausal symptoms

Exercise for vasomotor menopausal symptoms.

“No conclusions regarding the effectiveness of exercise as a treatment for vasomotor menopausal symptoms could be made due to a lack of trials.”

Cochrane Database Syst Rev. 2007 Oct 17;(4):CD006108.

Transdermal Estrogen for Menopausal Symptoms Review

A review of transdermal nonpatch estrogen therapy for the management of menopausal symptoms.

Estrogen therapy is used to the vasomotor symptoms of hot flushes and night sweats which can be severe. In Europe, transderaml estrogen therapy is most commonly prescribed. Transdermal 17beta-estradiol may have fewer health risks than oral estrogen therapy.

J Womens Health (Larchmt).  2010 Jan;19(1):47-55.

Transdermal estrogen avoids first-pass metabolism in the liver so that lower doses are required compared to oral estrogen which undergoes first-pass metabolism and reduces bioavailability.

Natural hormone therapy for menopause.

Natural hormone therapy for menopause.

“This paper reports a 12 plus months follow up on 189 patients who were administered natural estrogen plus progesterone with or without DHEA or testosterone according to a rationalized protocol described later.”

Gynecol Endocrinol. 2010 Feb;26(2):81-5.

Dehydroepiandrosterone (DHEA) is produced by adrenal glands and it acts on the androgen receptor.

Is Black Cohosh Safe?

Black cohosh (Cimicifuga racemosa) is used to treat menopausal symptoms. Black cohosh products should be labeled to include a cautionary statement about possible liver damage.

Black cohosh (Cimicifuga racemosa): a systematic review of adverse events.

Am J Obstet Gynecol. 2008 Nov;199(5):455-66.

United States Pharmacopeia review of the black cohosh case reports of hepatotoxicity.

Menopause. 2008 Jul-Aug;15(4 Pt 1):628-38.